If the patient is allergic to Paracetamol, Caffeine or any ingredient in the product; If the patient has high blood pressure or irregular heartbeat; Avoid long term use of Paracetamol in patients with anemia or with heart, lung, kidney, or liver disease; If the patient is recovering from severe alcoholism and taking Disulfiram. Disulfiram reduces Caffeine clearance, which might complicate alcohol withdrawal, increasing nervousness and restlessness; If the patient is below 12 years old; If the patient is taking these medicines: Medicines for high blood pressure (e.g., Propranolol, Atenolol) ; Caffeine can increase blood pressure and counter the blood pressure-lowering action of these medicines. Medicines for depression and anxiety (e.g., Sertraline, Clozapine), Lithium Carbonate. Decongestants containing Ephedrine Theophylline (for breathing problems); Caffeine and Theophylline share the same metabolic pathway which leads to increased clearance time for Theophylline when used together with Caffeine. Levothyroxine (for thyroid problems).
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